Association of Gout and Depression: A Systematic Review and Meta-Analysis痛风与抑郁的关联：一项系统综述与Meta分析
AbstractObjective:Several studies have shown that gout is associated with depression symptoms. In this study, a systematic review and meta-analysis was performed to explore the relationship between gout and depression.
Methods:Published articles were identified through a comprehensive review of PUBMED and EMBASE. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of depression among participants who had gout versus those without gout were analyzed. A random-effect model was used to calculate pooled odds ratios and 95% confident intervals (CI).
Results:Seven studies, which included 411 745 participants, aligned with our inclusion criteria and were included in the meta-analysis. Pooled analysis showed an association between gout and depression, with an odds ratio of 1.19 (95%CI, 1.11, 1.29; I2= 60.2%). Subgroup-analysis adjusted (or not) by study type or study quality showed a statistically significant association of gout and depression in all subgroups. Sensitivity analysis by 1-study removed analysis, excluding articles of self-reported gout assessment or male-only, confirmed the robustness of our results.
结果：7项研究，包含411745名受试者，符合我们的纳入标准，并被纳入meta分析。合并分析表明痛风与抑郁的关联OR=1.19（95%CI, 1.11, 1.29; I2= 60.2%）。根据研究类型或研究质量调整(或不调整)的亚组分析显示，痛风和抑郁症在所有亚组中均有统计学意义。通过逐个剔除法进行敏感性分析，排除了自我报告的痛风评估或只有男性报告的文章，证实了我们的结果的稳健性。
Conclusion:Our meta-analysis demonstrates a positive association between gout and depression. Further large-scale prospective cohort studies are needed to investigate the causality between gout and depression.
Keywords:depression; gout; meta-analysis; mood disorder.